https://www.resources.pitt.edu All HSCRF Computing & Data Analysis Cores Facilities _Analysis - Bioinformatics_ Bioinformatics Core Facility at the John G Rangos Sr. Research Center The Bioinformatics Core Facility at the John G. Rangos Sr. Research Center provides bioinformatics as well as biostatistics services across a wide range of disease domains. The next-generation sequencing data analysis includes, but is not limited to, whole genome-, whole exome-, bulk and single cell epigenome-, bulk and single cell transcriptome, spatial transcriptome, microbiome, metabolome, proteome and lipidome data analysis. The facility specializes in T-, and B- cell repertoire data analysis, multi-omics initiatives, and multimodal analysis. Shiny dashboard and other web application development is also supported. Cancer Bioinformatics Services, UPMC Hillman Cancer Center The Cancer Bioinformatics Services at UPMC Hillman Cancer Center provides bioinformatics support for translational genomics using sequencing, arrays, single cell, and other technologies. Genomics Analysis Core The Genomics Analysis Core focuses on bioinformatics analysis of genomic data with emphasis on rigor and reproducibility. Professional analytical staff support all aspects of translational studies - from experimental design to data analysis to publication. In Vivo Imaging Facility, UPMC Hillman Cancer Center (clinical research) The UPMC Hillman Cancer Center In Vivo Imaging Facility provides novel quantitative imaging assessments and metrics that include but not limited to standard FDA-approved clinical trial imaging assessments (such as RECIST, iRECIST, irRECIST, iiRC, RANO, Lugano, etc) to evaluate cancer therapy and more advanced AI imaging assessments using radiomics, radiogenomics, and AI-driven imaging biomarkers to enhance diagnostic, monitoring and post-therapy predictions and assessments. Single Cell Core The Single Cell Core provides library preparation and analysis using the 1X Genomics Chromium platform. All 1X Genomics single cell applications are fully supported including gene expression, V(D)J B cell and T cell immune profiling, ATAC, Multiome (gene expression with ATAC), cell surface protein markers and FLEX (single cell processing of FFPE tissue sections and formaldehyde fixed cells and tissues). The Single Cell Core can also work with researchers to pilot other single cell technologies. _Analysis - Biostatistics_ Biostatistics, Epidemiology and Research Design The Biostatistics, Epidemiology and Research Design Core of Pitt's Clinical and Translational Science Institute provides consultation regarding study design, statistical analyses, power and sample size calculations and data collection for clinical and translational studies and grant applications. BERD offers consultation for collecting and managing data using the REDCap system. BERD also offers a series of workshops to provide essential elements involved in data collection, data management and creating reports for research studies. Center for Biostatistics & Qualitative Methodology (CBQM) The Center for Biostatistics and Qualitative Methodology provides cutting-edge expertise and research infrastructure across 4 key Cores: Biostatistics, Data Management & Information Systems, Qualitative Analysis, and Data Coordination. Epidemiology Data Center, Pitt Public Health The Epidemiology Data Center at Pitt Public Health provides a research environment in which complex health questions can be explored and answered using the combined tools of biology and statistics. EDC establishes collaborations with clinical researchers to design, conduct and analyze multicenter, randomized clinical trials and epidemiological studies. In Vivo Imaging Facility, UPMC Hillman Cancer Center (clinical research) The UPMC Hillman Cancer Center In Vivo Imaging Facility provides novel quantitative imaging assessments and metrics that include but not limited to standard FDA-approved clinical trial imaging assessments (such as RECIST, iRECIST, irRECIST, iiRC, RANO, Lugano, etc) to evaluate cancer therapy and more advanced AI imaging assessments using radiomics, radiogenomics, and AI-driven imaging biomarkers to enhance diagnostic, monitoring and post-therapy predictions and assessments. _Analysis - Qualitative Data_ Center for Biostatistics & Qualitative Methodology (CBQM) The Center for Biostatistics and Qualitative Methodology provides cutting-edge expertise and research infrastructure across 4 key Cores: Biostatistics, Data Management & Information Systems, Qualitative Analysis, and Data Coordination. Genomics Analysis Core The Genomics Analysis Core focuses on bioinformatics analysis of genomic data with emphasis on rigor and reproducibility. Professional analytical staff support all aspects of translational studies - from experimental design to data analysis to publication. Pre-clinical In Vivo Imaging Facility, Hillman Cancer Center The Preclinical In Vivo Imaging Facility at UPMC Hillman Cancer Center offers MR, PET-CT, optical and ultrasound for small animals. UCSUR, University Center for Social & Urban Research UCSUR is a university center focused on community-engaged research. We serve Pitt researchers and the region. Services for hire include: (1) Geographic Information Systems (GIS) Analysis, Ellen Kinnee, ejk40@pitt.edu; (2) Regional Economic Analysis, Chris Briem, cbriem@pitt.edu; (3) Data Literacy & Accessibility such as developing dashboards, facilitating civic engagement, and transforming public data sources, Bob Gradeck, rmg44@pitt.edu; (4) Survey & Qualitative Research, Anita Zuberi, anita-zuberi@pitt.edu _Analysis - Statistics_ Animal Imaging Core Laboratory at the John G. Rangos Sr. Research Center The Animal Imaging Core Laboratory at the John G. Rangos Sr. Research Center provides in vivo and ex vivo multimodal imaging services (MRI, MRS, ultrasound, CT, PET, SPECT, and IVIS) and microinjection for all areas of preclinical anatomical imaging, functional imaging, and molecular imaging, from small rodents, rabbits, goats and pigs to nonhuman primates as well as non-biological samples. Center for Biostatistics & Qualitative Methodology (CBQM) The Center for Biostatistics and Qualitative Methodology provides cutting-edge expertise and research infrastructure across 4 key Cores: Biostatistics, Data Management & Information Systems, Qualitative Analysis, and Data Coordination. Statistics Consulting Center The Statistics Consulting Center offers services to the Pitt community at no charge. A program of the Department of Statistics, the center is staffed by departmental graduate students under faculty supervision. UCSUR, University Center for Social & Urban Research UCSUR is a university center focused on community-engaged research. We serve Pitt researchers and the region. Services for hire include: (1) Geographic Information Systems (GIS) Analysis, Ellen Kinnee, ejk40@pitt.edu; (2) Regional Economic Analysis, Chris Briem, cbriem@pitt.edu; (3) Data Literacy & Accessibility such as developing dashboards, facilitating civic engagement, and transforming public data sources, Bob Gradeck, rmg44@pitt.edu; (4) Survey & Qualitative Research, Anita Zuberi, anita-zuberi@pitt.edu _App Development_ Biostatistics Facility, UPMC Hillman Cancer Center The Biostatics Facility at UPMC Hillman Cancer Center provides statistical and computational methods for design, execution, analysis, and reporting of cancer-related research studies and trials including biomarker analysis and grant development. Shadyside, HCC Center for Biostatistics & Qualitative Methodology (CBQM) The Center for Biostatistics and Qualitative Methodology provides cutting-edge expertise and research infrastructure across 4 key Cores: Biostatistics, Data Management & Information Systems, Qualitative Analysis, and Data Coordination. Health Services Research Data Center (HSRDC) The Health Sciences Research Data Center is a HIPAA compliant secure computing environment where study teams can store data and do analytics from anywhere with internet access. Teams work in a Windows virtual desktop with memory, storage, and computing power dedicated to each user. Knowledgeable facility staff can provide data management, help with regulatory documents like DUAs, maintain systems compliance, and custom application development. Office of Academic Computing The Office of Academic Computing (OAC) supports research and provide technology services for the Department of Psychiatry research community. We design and build customized research applications for data collection, manage, and securely store research data, and provide end-user computing support for researchers in the department. _Computing & Software_ Cancer Bioinformatics Services, UPMC Hillman Cancer Center The Cancer Bioinformatics Services at UPMC Hillman Cancer Center provides bioinformatics support for translational genomics using sequencing, arrays, single cell, and other technologies. Center for Biostatistics & Qualitative Methodology (CBQM) The Center for Biostatistics and Qualitative Methodology provides cutting-edge expertise and research infrastructure across 4 key Cores: Biostatistics, Data Management & Information Systems, Qualitative Analysis, and Data Coordination. Center for Research Computing and Data Center for Research Computing provides access to computing and data storage resources, training workshops on how best to use these resources, and personalized consultation on improvements to research codes and workflows. Genomics Analysis Core The Genomics Analysis Core focuses on bioinformatics analysis of genomic data with emphasis on rigor and reproducibility. Professional analytical staff support all aspects of translational studies - from experimental design to data analysis to publication. Health Sciences Library System Molecular Biology Information Service The Health Sciences Library System Molecular Biology Information Service office maintains institutional licenses to a number of analytical software tools. Training workshops are offered regularly on how to use many of those packages, including those used for RNA-Seq and single-cell transcriptomics analysis. Health Services Research Data Center (HSRDC) The Health Sciences Research Data Center is a HIPAA compliant secure computing environment where study teams can store data and do analytics from anywhere with internet access. Teams work in a Windows virtual desktop with memory, storage, and computing power dedicated to each user. Knowledgeable facility staff can provide data management, help with regulatory documents like DUAs, maintain systems compliance, and custom application development. Pittsburgh Supercomputing Center The mission of the PIttsburgh Super Computing Center is to enable the advancement of science and research. The Center cultivates collaborative partnerships, empowers the next generation of researchers, and provides cutting-edge cyberinfrastructure. It strives to be the pioneering leader in advanced scientific computing and seeks to expand access to resources for breakthrough discoveries worldwide. UCSUR, University Center for Social & Urban Research UCSUR is a university center focused on community-engaged research. We serve Pitt researchers and the region. Services for hire include: (1) Geographic Information Systems (GIS) Analysis, Ellen Kinnee, ejk40@pitt.edu; (2) Regional Economic Analysis, Chris Briem, cbriem@pitt.edu; (3) Data Literacy & Accessibility such as developing dashboards, facilitating civic engagement, and transforming public data sources, Bob Gradeck, rmg44@pitt.edu; (4) Survey & Qualitative Research, Anita Zuberi, anita-zuberi@pitt.edu _Data Management/Coordination_ Cancer Bioinformatics Services, UPMC Hillman Cancer Center The Cancer Bioinformatics Services at UPMC Hillman Cancer Center provides bioinformatics support for translational genomics using sequencing, arrays, single cell, and other technologies. Center for Biostatistics & Qualitative Methodology (CBQM) The Center for Biostatistics and Qualitative Methodology provides cutting-edge expertise and research infrastructure across 4 key Cores: Biostatistics, Data Management & Information Systems, Qualitative Analysis, and Data Coordination. Genomics Analysis Core The Genomics Analysis Core focuses on bioinformatics analysis of genomic data with emphasis on rigor and reproducibility. Professional analytical staff support all aspects of translational studies - from experimental design to data analysis to publication. Health Research Record Request The Health Record Research Request (R3) is a service that provisions UPMC clinical data and authorizes UPMC data systems for research. R3 is available to University of Pittsburgh investigators and UPMC projects requiring research data. Under the Chief Research Informatics Officer (CRIO), on behalf of UPMC, staff provision data for research (in some cases as Honest Brokers) via our Research Data Warehouse, Neptune, and via other UPMC clinical data sources. The facility does not directly provide analysis services, but does enable collaborations with Department of Biomedical Informatics (DBMI) faculty and staff. Health Services Research Data Center (HSRDC) The Health Sciences Research Data Center is a HIPAA compliant secure computing environment where study teams can store data and do analytics from anywhere with internet access. Teams work in a Windows virtual desktop with memory, storage, and computing power dedicated to each user. Knowledgeable facility staff can provide data management, help with regulatory documents like DUAs, maintain systems compliance, and custom application development. Office of Academic Computing The Office of Academic Computing (OAC) supports research and provide technology services for the Department of Psychiatry research community. We design and build customized research applications for data collection, manage, and securely store research data, and provide end-user computing support for researchers in the department. UCSUR, University Center for Social & Urban Research UCSUR is a university center focused on community-engaged research. We serve Pitt researchers and the region. Services for hire include: (1) Geographic Information Systems (GIS) Analysis, Ellen Kinnee, ejk40@pitt.edu; (2) Regional Economic Analysis, Chris Briem, cbriem@pitt.edu; (3) Data Literacy & Accessibility such as developing dashboards, facilitating civic engagement, and transforming public data sources, Bob Gradeck, rmg44@pitt.edu; (4) Survey & Qualitative Research, Anita Zuberi, anita-zuberi@pitt.edu _Data Sources_ Cancer Bioinformatics Services, UPMC Hillman Cancer Center The Cancer Bioinformatics Services at UPMC Hillman Cancer Center provides bioinformatics support for translational genomics using sequencing, arrays, single cell, and other technologies. Genomics Analysis Core The Genomics Analysis Core focuses on bioinformatics analysis of genomic data with emphasis on rigor and reproducibility. Professional analytical staff support all aspects of translational studies - from experimental design to data analysis to publication. Health Research Record Request The Health Record Research Request (R3) is a service that provisions UPMC clinical data and authorizes UPMC data systems for research. R3 is available to University of Pittsburgh investigators and UPMC projects requiring research data. Under the Chief Research Informatics Officer (CRIO), on behalf of UPMC, staff provision data for research (in some cases as Honest Brokers) via our Research Data Warehouse, Neptune, and via other UPMC clinical data sources. The facility does not directly provide analysis services, but does enable collaborations with Department of Biomedical Informatics (DBMI) faculty and staff. National Retail Data Monitoring The National Retail Data Monitor tracks anonymous sales of the over-the-counter medications for the sole purpose of public health disease outbreak tracking and detection. UCSUR, University Center for Social & Urban Research UCSUR is a university center focused on community-engaged research. We serve Pitt researchers and the region. Services for hire include: (1) Geographic Information Systems (GIS) Analysis, Ellen Kinnee, ejk40@pitt.edu; (2) Regional Economic Analysis, Chris Briem, cbriem@pitt.edu; (3) Data Literacy & Accessibility such as developing dashboards, facilitating civic engagement, and transforming public data sources, Bob Gradeck, rmg44@pitt.edu; (4) Survey & Qualitative Research, Anita Zuberi, anita-zuberi@pitt.edu _Wet Labs with Analytical Support_ High Throughput Genome Center The High Throughput Genome Center supports high throughput paralleled sequencing for genome, transcriptome and epigenome analyses through Illumina and Oxford nanopore platforms, and array through Affymetrix platform. In addition, the center provides collaboration on single-cell transcriptome and multi-omic sequencing. For spatial biology, we provide Cytassist and Stereo-Seq platforms for transcriptome analysis. The center also provides extensive bioinformatic analyses to investigators through collaboration. Single Cell Core The Single Cell Core provides library preparation and analysis using the 1X Genomics Chromium platform. All 1X Genomics single cell applications are fully supported including gene expression, V(D)J B cell and T cell immune profiling, ATAC, Multiome (gene expression with ATAC), cell surface protein markers and FLEX (single cell processing of FFPE tissue sections and formaldehyde fixed cells and tissues). The Single Cell Core can also work with researchers to pilot other single cell technologies.